Do short-term tests predict rodent carcinogenicity?
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چکیده
منابع مشابه
Quantitative predictability of carcinogenicity of the covalent binding index of chemicals to DNA: comparison of the in vivo and in vitro assays.
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that this combination of three different tests gives the best overall concordance with rodent carcinogenicity. It is well known that the Ames test gives only just over 50% concordance with rodent carcinogenicity, but it is still extensively used. This is because it has a well-defined endpoint that one can readily understand in biological terms, i.e., genotoxicity. However, there is overwhelming...
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ورودعنوان ژورنال:
- Science
دوره 241 4870 شماره
صفحات -
تاریخ انتشار 1988